NFL game preview · Buffalo Bills vs Minnesota Vikings

Buffalo's top scoring offense meets Minnesota's top scoring defense, with Kyler Murray's hamstring unresolved

Two 6-1 teams meet with the best scoring offense facing the best scoring defense. Minnesota's passing offense is the clear weakness, and Kyler Murray is Questionable with a hamstring issue. The moneyline moved toward Buffalo while the spread and total barely changed.

Key numbers

Spread (MIN)
+3.5 opened +2.5
Total
45.5 opened 47
Moneyline
BUF -180 · MIN +150
Spread bets / money (MIN)
37% / 33%
Over bets / money
60% / 55%

Consensus across 36 sportsbooks.

Monday night pairs two 6-1 teams, and the central question is a clean collision: the top-ranked scoring offense against the top-ranked scoring defense. Buffalo scores 33.3 points per game, rank 1. Minnesota allows 13.3 points per game, rank 1. Minnesota is coming off a 15-19 road loss, while Buffalo beat Baltimore 36-10 at home. Each team has played only seven games, so the ranks carry some noise.

The underlying numbers do not point one way. Buffalo gains 6.33 yards per play, rank 2, and rushes for 148.4 yards per game, rank 3. Minnesota's defense allows 4.66 yards per play, rank 2, but its rushing defense is ordinary at 116.7 yards allowed per game, rank 17. Buffalo's defense is the soft side of the matchup: it allows 254.7 passing yards per game, rank 30, and 25.9 points per game, rank 24.

That is where Minnesota would want to attack, and the Vikings' offense has struggled to do so. They average 165.6 passing yards per game, rank 31, and 4.74 yards per play, rank 29. Over their last four games they score 17.3 points per game. Kyler Murray is the quarterback, but he is Questionable with a sore hamstring and is undergoing a full evaluation. Offensive tackle Christian Darrisaw is also Questionable. Justin Jefferson has 23 targets over the last three games, #1 among Minnesota's receivers, and a report says he was frustrated after Sunday's loss.

Buffalo has absences up front. Offensive tackle Spencer Brown is Out with a back issue, and Minnesota's defense produces 3.57 sacks per game. DJ Moore is Questionable after leaving late in Sunday's game with a knee issue, though he said afterward that he is okay. Josh Allen is Buffalo's quarterback.

The market sits at Buffalo -3.5, up from an opening of Buffalo -2.5, and that spread move is classed as minor. The moneyline shift is larger: Buffalo is -180 and Minnesota +149, and Minnesota's implied win probability went from 45% to 40.2%, a notable move. The total is 46.5, exactly where it opened.

The scoring evidence conflicts. Minnesota has gone under the total in six straight games, and only 14.3% of its games have gone over the closing total. Buffalo has gone over in four straight road games, and 71.4% of its games overall have gone over. Those are descriptions of what has happened, not forecasts. The matchup numbers can support a low-scoring game, since Minnesota's offense is weak, or a higher-scoring one, since Buffalo's pass defense is porous. Public betting splits are not available, and Murray's final status is not known.

Buffalo Bills vs Minnesota Vikings: FAQ

When is Buffalo Bills vs Minnesota Vikings?

Buffalo Bills at Minnesota Vikings kicks off Monday, November 9, 2026 at 8:15 PM ET.

Who is favored in Buffalo Bills vs Minnesota Vikings?

Buffalo Bills is a 3.5-point favorite (consensus across 36 sportsbooks). The line opened at Minnesota Vikings +2.5.

What is the over/under for Buffalo Bills vs Minnesota Vikings?

The consensus total is 45.5, after opening at 47.

Where is the public betting on Buffalo Bills vs Minnesota Vikings?

On the spread, 37% of bets and 33% of the money are on Minnesota Vikings; 63% of bets and 67% of the money are on Buffalo Bills.

AI-assisted analysis for entertainment. Prices move; check your book before you bet. 21+. Gambling problem? Call 1-800-GAMBLER.